Activation of Cyclic AMP Signaling Leads to Different Pathway Alterations in Lesions of the Adrenal Cortex Caused by Germline PRKAR1A Defects versus Those due to Somatic GNAS Mutations

CONTEXT: The overwhelming majority of benign lesions of the adrenal cortex leading to Cushing syndrome are linked to one or another abnormality of the cAMP or protein kinase pathway. PRKAR1A-inactivating mutations are responsible for primary pigmented nodular adrenocortical disease, whereas somatic...

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Detalhes bibliográficos
Main Authors: Almeida, Madson Q., Azevedo, Monalisa F., Xekouki, Paraskevi, Bimpaki, Eirini I., Horvath, Anelia, Collins, Michael T., Karaviti, Lefkothea P., Jeha, George S., Bhattacharyya, Nisan, Cheadle, Chris, Watkins, Tonya, Bourdeau, Isabelle, Nesterova, Maria, Stratakis, Constantine A.
Formato: Artigo
Idioma:Inglês
Publicado em: Endocrine Society 2012
Assuntos:
JCEM Online: Advances in Genetics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3319183/
https://ncbi.nlm.nih.gov/pubmed/22259056
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/jc.2011-3000
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