Alterations in the regulation of androgen-sensitive Cyp 4a monooxygenases cause hypertension

Hypertension is a leading cause of cardiovascular, cerebral, and renal disease morbidity and mortality. Here we show that disruption of the Cyp 4a14 gene causes hypertension, which is, like most human hypertension, more severe in males. Male Cyp 4a14 (−/−) mice show increases in plasma androgens, ki...

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發表在:	Proc Natl Acad Sci U S A
Principais autores:	Holla, Vijaykumar R., Adas, Fadi, Imig, John D., Zhao, Xueying, Price, Edward, Olsen, Nancy, Kovacs, William J., Magnuson, Mark A., Keeney, Diane S., Breyer, Matthew D., Falck, John R., Waterman, Michael R., Capdevila, Jorge H.
格式:	Artigo
語言:	Inglês
出版:	National Academy of Sciences 2001
主題:	Biological Sciences
在線閱讀:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC33189/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11320253/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.081627898
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