Alterations in the regulation of androgen-sensitive Cyp 4a monooxygenases cause hypertension
Hypertension is a leading cause of cardiovascular, cerebral, and renal disease morbidity and mortality. Here we show that disruption of the Cyp 4a14 gene causes hypertension, which is, like most human hypertension, more severe in males. Male Cyp 4a14 (−/−) mice show increases in plasma androgens, ki...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Principais autores: | , , , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2001
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC33189/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11320253/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.081627898 |
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