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Alterations in the regulation of androgen-sensitive Cyp 4a monooxygenases cause hypertension

Hypertension is a leading cause of cardiovascular, cerebral, and renal disease morbidity and mortality. Here we show that disruption of the Cyp 4a14 gene causes hypertension, which is, like most human hypertension, more severe in males. Male Cyp 4a14 (−/−) mice show increases in plasma androgens, ki...

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Yayımlandı:Proc Natl Acad Sci U S A
Asıl Yazarlar: Holla, Vijaykumar R., Adas, Fadi, Imig, John D., Zhao, Xueying, Price, Edward, Olsen, Nancy, Kovacs, William J., Magnuson, Mark A., Keeney, Diane S., Breyer, Matthew D., Falck, John R., Waterman, Michael R., Capdevila, Jorge H.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: National Academy of Sciences 2001
Konular:
Biological Sciences
Online Erişim:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC33189/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11320253/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.081627898
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