The Histone Deacetylase Inhibitor Valproic Acid Lessens NK Cell Action against Oncolytic Virus-Infected Glioblastoma Cells by Inhibition of STAT5/T-BET Signaling and Generation of Gamma Interferon

Tumor virotherapy has been and continues to be used in clinical trials. One barrier to effective viral oncolysis, consisting of the interferon (IFN) response induced by viral infection, is inhibited by valproic acid (VPA) and other histone deacetylase inhibitors (HDACi). Innate immune cell recruitme...

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Bibliografische gegevens
Hoofdauteurs: Alvarez-Breckenridge, Christopher A., Yu, Jianhua, Price, Richard, Wei, Min, Wang, Yan, Nowicki, Michal O., Ha, Yoonhee P., Bergin, Stephen, Hwang, Christine, Fernandez, Soledad A., Kaur, Balveen, Caligiuri, Michael A., Chiocca, E. Antonio
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Microbiology 2012
Onderwerpen:
Cellular Response to Infection
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3318659/
https://ncbi.nlm.nih.gov/pubmed/22318143
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.05545-11
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