The Histone Deacetylase Inhibitor Valproic Acid Lessens NK Cell Action against Oncolytic Virus-Infected Glioblastoma Cells by Inhibition of STAT5/T-BET Signaling and Generation of Gamma Interferon

Tumor virotherapy has been and continues to be used in clinical trials. One barrier to effective viral oncolysis, consisting of the interferon (IFN) response induced by viral infection, is inhibited by valproic acid (VPA) and other histone deacetylase inhibitors (HDACi). Innate immune cell recruitme...

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Main Authors: Alvarez-Breckenridge, Christopher A., Yu, Jianhua, Price, Richard, Wei, Min, Wang, Yan, Nowicki, Michal O., Ha, Yoonhee P., Bergin, Stephen, Hwang, Christine, Fernandez, Soledad A., Kaur, Balveen, Caligiuri, Michael A., Chiocca, E. Antonio
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society for Microbiology 2012
Ábhair:
Cellular Response to Infection
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3318659/
https://ncbi.nlm.nih.gov/pubmed/22318143
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.05545-11
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