A Serotype 3 Pneumococcal Capsular Polysaccharide-Specific Monoclonal Antibody Requires Fcγ Receptor III and Macrophages To Mediate Protection against Pneumococcal Pneumonia in Mice

Antibodies to pneumococcal capsular polysaccharide (PPS) are required for PPS-based vaccine-mediated protection against Streptococcus pneumoniae. Previous work established that 1E2, a mouse IgG1 to PPS3 that does not induce serotype 3 (ST3) S. pneumoniae killing by phagocytes in vitro, protects mice...

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Bibliographic Details
Main Authors: Weber, Sarah, Tian, Haijun, van Rooijen, Nico, Pirofski, Liise-anne
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2012
Subjects:
Microbial Immunity and Vaccines
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3318404/
https://ncbi.nlm.nih.gov/pubmed/22290146
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.06081-11
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