Confirmation of fenfluramine effect on 5-HT(1B) receptor binding of [(11)C]AZ10419369 using an equilibrium approach

Assessment of serotonin release in the living brain with positron emission tomography (PET) may have been hampered by the lack of suitable radioligands. We previously reported that fenfluramine caused a dose-dependent reduction in specific binding in monkeys using a classical displacement paradigm w...

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Hlavní autoři: Finnema, Sjoerd J, Varrone, Andrea, Hwang, Tzung-Jeng, Halldin, Christer, Farde, Lars
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2012
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Original Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3318146/
https://ncbi.nlm.nih.gov/pubmed/22167236
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/jcbfm.2011.172
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