Confirmation of fenfluramine effect on 5-HT(1B) receptor binding of [(11)C]AZ10419369 using an equilibrium approach

Assessment of serotonin release in the living brain with positron emission tomography (PET) may have been hampered by the lack of suitable radioligands. We previously reported that fenfluramine caused a dose-dependent reduction in specific binding in monkeys using a classical displacement paradigm w...

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Главные авторы: Finnema, Sjoerd J, Varrone, Andrea, Hwang, Tzung-Jeng, Halldin, Christer, Farde, Lars
Формат: Artigo
Язык:Inglês
Опубликовано: Nature Publishing Group 2012
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Original Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3318146/
https://ncbi.nlm.nih.gov/pubmed/22167236
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/jcbfm.2011.172
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