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Highly Perturbed pK(a) Values in the Unfolded State of Hen Egg White Lysozyme
The majority of pK(a) values in protein unfolded states are close to the amino acid model pK(a) values, thus reflecting the weak intramolecular interactions present in the unfolded ensemble of most proteins. We have carried out thermal denaturation measurements on the WT and eight mutants of HEWL fr...
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| Hauptverfasser: | , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
The Biophysical Society
2012
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3318136/ https://ncbi.nlm.nih.gov/pubmed/22500764 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2012.02.048 |
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