A Novel Intracellular Isoform of Matrix Metalloproteinase-2 Induced by Oxidative Stress Activates Innate Immunity

BACKGROUND: Experimental and clinical evidence has pinpointed a critical role for matrix metalloproteinase-2 (MMP-2) in ischemic ventricular remodeling and systolic heart failure. Prior studies have demonstrated that transgenic expression of the full-length, 68 kDa, secreted form of MMP-2 induces se...

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Detalhes bibliográficos
Main Authors: Lovett, David H., Mahimkar, Rajeev, Raffai, Robert L., Cape, Leslie, Maklashina, Elena, Cecchini, Gary, Karliner, Joel S.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3317925/
https://ncbi.nlm.nih.gov/pubmed/22509276
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0034177
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