Palmitoylation and membrane cholesterol stabilize μ-opioid receptor homodimerization and G protein coupling

BACKGROUND: A cholesterol-palmitoyl interaction has been reported to occur in the dimeric interface of the β(2)-adrenergic receptor crystal structure. We sought to investigate whether a similar phenomenon could be observed with μ-opioid receptor (OPRM1), and if so, to assess the role of cholesterol...

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Autors principals: Zheng, Hui, Pearsall, Elizabeth A, Hurst, Dow P, Zhang, Yuhan, Chu, Ji, Zhou, Yali, Reggio, Patricia H, Loh, Horace H, Law, Ping-Yee
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2012
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3317874/
https://ncbi.nlm.nih.gov/pubmed/22429589
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2121-13-6
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