Retinoblastoma Treatment: Utilization of the Glycolytic Inhibitor, 2-deoxy-2-fluoro-d-glucose (2-FG), to Target the Chemoresistant Hypoxic Regions in LH(BETA)T(AG) Retinal Tumors

PURPOSE. To analyze the effect of the glycolytic inhibitor 2-deoxy-2-fluoro-d-glucose (2-FG) on tumor burden, hypoxia, and blood vessels in LH(BETA)T(AG) retinal tumors. METHODS. Seventeen-week-old LH(BETA)T(AG) retinal tumor eyes (n = 36) were treated with 2-FG and analyzed at 1 day and 1 week post...

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Main Authors: Piña, Yolanda, Decatur, Christina, Murray, Timothy G., Houston, Samuel K., Lopez-Cavalcante, Milena, Hernandez, Eleut, Celdran, Magda, Shah, Nikesh, Feuer, William, Lampidis, Theodore
Format: Artigo
Language:Inglês
Published: Association for Research in Vision and Ophthalmology, Inc. 2012
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3317436/
https://ncbi.nlm.nih.gov/pubmed/22266512
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/iovs.11-8265
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