C16 ceramide is crucial for triacylglycerol-induced apoptosis in macrophages

Triacylglycerol (TG) accumulation caused by adipose triglyceride lipase (ATGL) deficiency or very low-density lipoprotein (VLDL) loading of wild-type (Wt) macrophages results in mitochondrial-mediated apoptosis. This phenotype is correlated to depletion of Ca(2+) from the endoplasmic reticulum (ER),...

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Autors principals: Aflaki, E, Doddapattar, P, Radović, B, Povoden, S, Kolb, D, Vujić, N, Wegscheider, M, Koefeler, H, Hornemann, T, Graier, W F, Malli, R, Madeo, F, Kratky, D
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2012
Matèries:
Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3317349/
https://ncbi.nlm.nih.gov/pubmed/22419109
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2012.17
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