Triacylglycerol Accumulation Activates the Mitochondrial Apoptosis Pathway in Macrophages

Programmed cell death of lipid-laden macrophages is a prominent feature of atherosclerotic lesions and mostly ascribed to accumulation of excess intracellular cholesterol. The present in vitro study investigated whether intracellular triacylglycerol (TG) accumulation could activate a similar apoptot...

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Auteurs principaux: Aflaki, Elma, Radović, Branislav, Chandak, Prakash G., Kolb, Dagmar, Eisenberg, Tobias, Ring, Julia, Fertschai, Ismene, Uellen, Andreas, Wolinski, Heimo, Kohlwein, Sepp-Dieter, Zechner, Rudolf, Levak-Frank, Sanja, Sattler, Wolfgang, Graier, Wolfgang F., Malli, Roland, Madeo, Frank, Kratky, Dagmar
Format: Artigo
Langue:Inglês
Publié: American Society for Biochemistry and Molecular Biology 2011
Sujets:
Lipids
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3044998/
https://ncbi.nlm.nih.gov/pubmed/21196579
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.175703
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