Raf kinases mediate the phosphorylation of eukaryotic translation elongation factor 1A and regulate its stability in eukaryotic cells

We identified eukaryotic translation elongation factor 1A (eEF1A) Raf-mediated phosphorylation sites and defined their role in the regulation of eEF1A half-life and of apoptosis of human cancer cells. Mass spectrometry identified in vitro S21 and T88 as phosphorylation sites mediated by B-Raf but no...

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Main Authors: Sanges, C, Scheuermann, C, Zahedi, R P, Sickmann, A, Lamberti, A, Migliaccio, N, Baljuls, A, Marra, M, Zappavigna, S, Rapp, U, Abbruzzese, A, Caraglia, M, Arcari, P
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group 2012
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Original Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3317347/
https://ncbi.nlm.nih.gov/pubmed/22378069
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2012.16
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