After the bottleneck: Genome-wide diversification of the Mycobacterium tuberculosis complex by mutation, recombination, and natural selection

Many of the most virulent bacterial pathogens show low genetic diversity and sexual isolation. Accordingly, Mycobacterium tuberculosis, the deadliest human pathogen, is thought to be clonal and evolve by genetic drift. Yet, its genome shows few of the concomitant signs of genome degradation. We anal...

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Bibliographic Details
Main Authors: Namouchi, Amine, Didelot, Xavier, Schöck, Ulrike, Gicquel, Brigitte, Rocha, Eduardo P.C.
Format: Artigo
Language:Inglês
Published: Cold Spring Harbor Laboratory Press 2012
Subjects:
Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3317154/
https://ncbi.nlm.nih.gov/pubmed/22377718
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.129544.111
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