Tumor Necrosis Factor Alpha Mediates GABA(A) Receptor Trafficking to the Plasma Membrane of Spinal Cord Neurons In Vivo

The proinflammatory cytokine TNFα contributes to cell death in central nervous system (CNS) disorders by altering synaptic neurotransmission. TNFα contributes to excitotoxicity by increasing GluA2-lacking AMPA receptor (AMPAR) trafficking to the neuronal plasma membrane. In vitro, increased AMPAR on...

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Autores principales: Stück, Ellen D., Christensen, Randolph N., Huie, J. Russell, Tovar, C. Amy, Miller, Brandon A., Nout, Yvette S., Bresnahan, Jacqueline C., Beattie, Michael S., Ferguson, Adam R.
Formato: Artigo
Lenguaje:Inglês
Publicado: Hindawi Publishing Corporation 2012
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3317039/
https://ncbi.nlm.nih.gov/pubmed/22530155
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2012/261345
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