Tumor Necrosis Factor Alpha Mediates GABA(A) Receptor Trafficking to the Plasma Membrane of Spinal Cord Neurons In Vivo

The proinflammatory cytokine TNFα contributes to cell death in central nervous system (CNS) disorders by altering synaptic neurotransmission. TNFα contributes to excitotoxicity by increasing GluA2-lacking AMPA receptor (AMPAR) trafficking to the neuronal plasma membrane. In vitro, increased AMPAR on...

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Detalhes bibliográficos
Main Authors: Stück, Ellen D., Christensen, Randolph N., Huie, J. Russell, Tovar, C. Amy, Miller, Brandon A., Nout, Yvette S., Bresnahan, Jacqueline C., Beattie, Michael S., Ferguson, Adam R.
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi Publishing Corporation 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3317039/
https://ncbi.nlm.nih.gov/pubmed/22530155
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2012/261345
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