Tumor Necrosis Factor Alpha Mediates GABA(A) Receptor Trafficking to the Plasma Membrane of Spinal Cord Neurons In Vivo

The proinflammatory cytokine TNFα contributes to cell death in central nervous system (CNS) disorders by altering synaptic neurotransmission. TNFα contributes to excitotoxicity by increasing GluA2-lacking AMPA receptor (AMPAR) trafficking to the neuronal plasma membrane. In vitro, increased AMPAR on...

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Bibliographic Details
Main Authors: Stück, Ellen D., Christensen, Randolph N., Huie, J. Russell, Tovar, C. Amy, Miller, Brandon A., Nout, Yvette S., Bresnahan, Jacqueline C., Beattie, Michael S., Ferguson, Adam R.
Format: Artigo
Language:Inglês
Published: Hindawi Publishing Corporation 2012
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3317039/
https://ncbi.nlm.nih.gov/pubmed/22530155
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2012/261345
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