Host gene targets for novel influenza therapies elucidated by high‐throughput RNA interference screens

Influenza virus encodes only 11 viral proteins but replicates in a broad range of avian and mammalian species by exploiting host cell functions. Genome‐wide RNA interference (RNAi) has proven to be a powerful tool for identifying the host molecules that participate in each step of virus replication....

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Autori principali: Meliopoulos, Victoria A., Andersen, Lauren E., Birrer, Katherine F., Simpson, Kaylene J., Lowenthal, John W., Bean, Andrew G. D., Stambas, John, Stewart, Cameron R., Tompkins, S. Mark, van Beusechem, Victor W., Fraser, Iain, Mhlanga, Musa, Barichievy, Samantha, Smith, Queta, Leake, Devin, Karpilow, Jon, Buck, Amy, Jona, Ghil, Tripp, Ralph A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Federation of American Societies for Experimental Biology 2012
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Review
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3316894/
https://ncbi.nlm.nih.gov/pubmed/22247330
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.11-193466
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