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FoxOs Integrate Pleiotropic Actions Of Insulin In Vascular Endothelium To Protect Mice From Atherosclerosis
Atherosclerotic cardiovascular disease is the leading cause of death in insulin-resistant (type 2) diabetes. Vascular endothelial dysfunction paves the way for atherosclerosis through impaired nitric oxide availability, inflammation, and generation of superoxide. Surprisingly, we show that ablation...
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Κύριοι συγγραφείς: | , , , , , , , , |
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Μορφή: | Artigo |
Γλώσσα: | Inglês |
Έκδοση: |
2012
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Θέματα: | |
Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3315846/ https://ncbi.nlm.nih.gov/pubmed/22405072 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2012.01.018 |
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