Pharmacokinetic Modeling of an Induction Regimen for In Vivo Combined Testing of Novel Drugs against Pediatric Acute Lymphoblastic Leukemia Xenografts

Current regimens for induction therapy of pediatric acute lymphoblastic leukemia (ALL), or for re-induction post relapse, use a combination of vincristine (VCR), a glucocorticoid, and l-asparaginase (ASP) with or without an anthracycline. With cure rates now approximately 80%, robust pre-clinical mo...

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Main Authors: Szymanska, Barbara, Wilczynska-Kalak, Urszula, Kang, Min H., Liem, Natalia L. M., Carol, Hernan, Boehm, Ingrid, Groepper, Daniel, Reynolds, C. Patrick, Stewart, Clinton F., Lock, Richard B.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3315513/
https://ncbi.nlm.nih.gov/pubmed/22479469
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0033894
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