LMW-E/CDK2 Deregulates Acinar Morphogenesis, Induces Tumorigenesis, and Associates with the Activated b-Raf-ERK1/2-mTOR Pathway in Breast Cancer Patients

Elastase-mediated cleavage of cyclin E generates low molecular weight cyclin E (LMW-E) isoforms exhibiting enhanced CDK2–associated kinase activity and resistance to inhibition by CDK inhibitors p21 and p27. Approximately 27% of breast cancers express high LMW-E protein levels, which significantly c...

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Главные авторы: Duong, MyLinh T., Akli, Said, Wei, Caimiao, Wingate, Hannah F., Liu, Wenbin, Lu, Yiling, Yi, Min, Mills, Gordon B., Hunt, Kelly K., Keyomarsi, Khandan
Формат: Artigo
Язык:Inglês
Опубликовано: Public Library of Science 2012
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Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3315462/
https://ncbi.nlm.nih.gov/pubmed/22479189
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1002538
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