Haploinsufficiency of SGO1 results in deregulated centrosome dynamics, enhanced chromosomal instability and colon tumorigenesis

Chromosome instability (CIN) is found in 85% of colorectal cancers. Defects in mitotic processes are implicated in high CIN and may be critical events in colorectal tumorigenesis. Shugoshin-1 (SGO1) aids in the maintenance of chromosome cohesion and prevents premature chromosome separation and CIN....

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Autors principals: Yamada, Hiroshi Y, Yao, Yixin, Wang, Xiaoxing, Zhang, Yuting, Huang, Ying, Dai, Wei, Rao, Chinthalapally V
Format: Artigo
Idioma:Inglês
Publicat: Landes Bioscience 2012
Matèries:
Report
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3315092/
https://ncbi.nlm.nih.gov/pubmed/22262168
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cc.11.3.18994
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