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Inhibitors of human histone deacetylase with potent activity against the African trypanosome Trypanosoma brucei
A number of hydroxamic acid derivatives which inhibit human histone deacetylases were investigated for efficacy against cultured bloodstream form Trypanosoma brucei. Three out of the four classes tested displayed significant activity. The majority of compounds blocked parasite growth in the submicro...
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| Main Authors: | , , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Elsevier Science Ltd
2012
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3314994/ https://ncbi.nlm.nih.gov/pubmed/22326398 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2012.01.072 |
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