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COMT Val(158)Met Genotype Determines the Direction of Cognitive Effects Produced by Catechol-O-Methyltransferase Inhibition

BACKGROUND: Catechol-O-methyltransferase (COMT) metabolizes dopamine. The COMT Val(158)Met polymorphism influences its activity, and multiple neural correlates of this genotype on dopaminergic phenotypes, especially working memory, have been reported. COMT activity can also be regulated pharmacologi...

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Bibliografski detalji
Glavni autori: Farrell, Sarah M., Tunbridge, Elizabeth M., Braeutigam, Sven, Harrison, Paul J.
Format: Artigo
Jezik:Inglês
Izdano: Elsevier 2012
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3314969/
https://ncbi.nlm.nih.gov/pubmed/22364739
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biopsych.2011.12.023
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