COMT Val(158)Met Genotype Determines the Direction of Cognitive Effects Produced by Catechol-O-Methyltransferase Inhibition

BACKGROUND: Catechol-O-methyltransferase (COMT) metabolizes dopamine. The COMT Val(158)Met polymorphism influences its activity, and multiple neural correlates of this genotype on dopaminergic phenotypes, especially working memory, have been reported. COMT activity can also be regulated pharmacologi...

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Hlavní autoři: Farrell, Sarah M., Tunbridge, Elizabeth M., Braeutigam, Sven, Harrison, Paul J.
Médium: Artigo
Jazyk:Inglês
Vydáno: Elsevier 2012
Témata:
Archival Report
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3314969/
https://ncbi.nlm.nih.gov/pubmed/22364739
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biopsych.2011.12.023
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