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Salmonella Virulence Effector SopE and Host GEF ARNO Cooperate to Recruit and Activate WAVE to Trigger Bacterial Invasion

Salmonella virulence effectors elicit host cell membrane ruffling to facilitate pathogen invasion. The WAVE regulatory complex (WRC) governs the underlying membrane-localized actin polymerization, but how Salmonella manipulates WRC is unknown. We show that Rho GTPase activation by the Salmonella gua...

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Detalhes bibliográficos
Main Authors: Humphreys, Daniel, Davidson, Anthony, Hume, Peter J., Koronakis, Vassilis
Formato: Artigo
Idioma:Inglês
Publicado em: Cell Press 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3314957/
https://ncbi.nlm.nih.gov/pubmed/22341462
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chom.2012.01.006
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