Salmonella Typhimurium reprograms macrophage metabolism via T3SS effector SopE2 to promote intracellular replication and virulence

Salmonella Typhimurium establishes systemic infection by replicating in host macrophages. Here we show that macrophages infected with S. Typhimurium exhibit upregulated glycolysis and decreased serine synthesis, leading to accumulation of glycolytic intermediates. The effects on serine synthesis are...

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Pubblicato in:Nat Commun
Autori principali: Jiang, Lingyan, Wang, Peisheng, Song, Xiaorui, Zhang, Huan, Ma, Shuangshuang, Wang, Jingting, Li, Wanwu, Lv, Runxia, Liu, Xiaoqian, Ma, Shuai, Yan, Jiaqi, Zhou, Haiyan, Huang, Di, Cheng, Zhihui, Yang, Chen, Feng, Lu, Wang, Lei
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2021
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7873081/
https://ncbi.nlm.nih.gov/pubmed/33563986
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-21186-4
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