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Antitumor activities of ATP-competitive inhibitors of mTOR in colon cancer cells
BACKGROUND: The mammalian target of rapamycin (mTOR) is frequently activated in colon cancers due to mutations in the phosphatidylinositol 3-kinase (PI3K) pathway. Targeting mTOR with allosteric inhibitors of mTOR such as rapamycin reduces colon cancer progression in several experimental models. Rec...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
BioMed Central
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3314574/ https://ncbi.nlm.nih.gov/pubmed/22401294 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2407-12-86 |
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