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The application of the AMB protective group in the solid-phase synthesis of methylphosphonate DNA analogues.
Partially methylphosphonate-modified oligodeoxynucleotides were synthesized on solid-phase by employing the easily removable 2-(acetoxymethyl)benzoyl (AMB) group as base-protecting group. Although a rapid AMB deprotection can be accomplished in methanolic potassium carbonate, the lability of the met...
Αποθηκεύτηκε σε:
| Κύριοι συγγραφείς: | , , , |
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| Μορφή: | Artigo |
| Γλώσσα: | Inglês |
| Έκδοση: |
1993
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| Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC331450/ https://ncbi.nlm.nih.gov/pubmed/8346028 |
| Ετικέτες: |
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