The application of the AMB protective group in the solid-phase synthesis of methylphosphonate DNA analogues.

Partially methylphosphonate-modified oligodeoxynucleotides were synthesized on solid-phase by employing the easily removable 2-(acetoxymethyl)benzoyl (AMB) group as base-protecting group. Although a rapid AMB deprotection can be accomplished in methanolic potassium carbonate, the lability of the met...

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Main Authors: Kuijpers, W H, Kuyl-Yeheskiely, E, van Boom, J H, van Boeckel, C A
Format: Artigo
Sprog:Inglês
Udgivet: 1993
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC331450/
https://ncbi.nlm.nih.gov/pubmed/8346028
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