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The application of the AMB protective group in the solid-phase synthesis of methylphosphonate DNA analogues.
Partially methylphosphonate-modified oligodeoxynucleotides were synthesized on solid-phase by employing the easily removable 2-(acetoxymethyl)benzoyl (AMB) group as base-protecting group. Although a rapid AMB deprotection can be accomplished in methanolic potassium carbonate, the lability of the met...
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| Publicado no: | Nucleic Acids Res |
|---|---|
| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
1993
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| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC331450/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8346028/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/21.15.3493 |
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