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Synthesis of oligodeoxynucleoside methylphosphonates utilizing the tert-butylphenoxyacetyl group for exocyclic amine protection.

Oligodeoxynucleoside methylphosphonates were synthesized using methylphosphonamidite monomers incorporating the base labile tert-butylphenoxyacetyl (t-BPA) protecting group on the exocyclic amines of dA, dC, and dG. Synthesis of the oligodeoxynucleoside methylphosphonates required only a small chang...

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Publicat a:Nucleic Acids Res
Autors principals: Sinha, N D, Michaud, D P, Roy, S K, Casale, R A
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 1994
Accés en línia:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC310284/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8065925/
https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/22.15.3119
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