Applied molecular evolution of O(6)-benzylguanine-resistant DNA alkyltransferases in human hematopoietic cells

Applied molecular evolution is a rapidly developing technology that can be used to create and identify novel enzymes that nature has not selected. An important application of this technology is the creation of highly drug-resistant enzymes for cancer gene therapy. Seventeen O(6)-alkylguanine-DNA alk...

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Publicat a:	Proc Natl Acad Sci U S A
Autors principals:	Davis, Brian M., Encell, Lance P., Zielske, Steven P., Christians, Fred C., Liu, Lili, Friebert, Sarah E., Loeb, Lawrence A., Gerson, Stanton L.
Format:	Artigo
Idioma:	Inglês
Publicat:	National Academy of Sciences 2001
Matèries:	Biological Sciences
Accés en línia:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC33144/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11296271/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.091601198
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