Ubiquitin Ligase Smurf1 Controls Osteoblast Activity and Bone Homeostasis by Targeting MEKK2 for Degradation

Bone is constantly resorbed and formed throughout life by coordinated actions of osteoclasts and osteoblasts. Here we show that Smurf1, a HECT domain ubiquitin ligase, has a specific physiological role in suppressing the osteogenic activity of osteoblasts. Smurf1-deficient mice are born normal but e...

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Main Authors: Yamashita, Motozo, Ying, Sai-Xia, Zhang, Gen-mu, Li, Cuiling, Cheng, Steven Y., Deng, Chu-xia, Zhang, Ying E.
Formato: Artigo
Idioma:Inglês
Publicado: 2005
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3314294/
https://ncbi.nlm.nih.gov/pubmed/15820682
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2005.01.035
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