Ubiquitin Ligase Smurf1 Mediates Tumor Necrosis Factor-induced Systemic Bone Loss by Promoting Proteasomal Degradation of Bone Morphogenetic Signaling Proteins

Chronic inflammatory disorders, such as rheumatoid arthritis, are often accompanied by systemic bone loss, which is thought to occur through inflammatory cytokine-mediated stimulation of osteoclast resorption and inhibition of osteoblast function. However, the mechanisms involved in osteoblast inhib...

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Opis bibliograficzny
Główni autorzy: Guo, Ruolin, Yamashita, Motozo, Zhang, Qian, Zhou, Quan, Chen, Di, Reynolds, David G., Awad, Hani A., Yanoso, Laura, Zhao, Lan, Schwarz, Edward M., Zhang, Ying E., Boyce, Brendan F., Xing, Lianping
Format: Artigo
Język:Inglês
Wydane: American Society for Biochemistry and Molecular Biology 2008
Hasła przedmiotowe:
Mechanisms of Signal Transduction
Dostęp online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2517001/
https://ncbi.nlm.nih.gov/pubmed/18567580
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M709848200
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