Automated image analysis of nuclear shape: What can we learn from a prematurely aged cell?

The premature aging disorder, Hutchinson-Gilford progeria syndrome (HGPS), is caused by mutant lamin A, which affects the nuclear scaffolding. The phenotypic hallmark of HGPS is nuclear blebbing. Interestingly, similar nuclear blebbing has also been observed in aged cells from healthy individuals. R...

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Detaylı Bibliyografya
Asıl Yazarlar: Driscoll, Meghan K., Albanese, Jason L., Xiong, Zheng-Mei, Mailman, Mitch, Losert, Wolfgang, Cao, Kan
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Impact Journals LLC 2012
Konular:
Research Paper
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3314174/
https://ncbi.nlm.nih.gov/pubmed/22354768
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