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Automated image analysis of nuclear shape: What can we learn from a prematurely aged cell?

The premature aging disorder, Hutchinson-Gilford progeria syndrome (HGPS), is caused by mutant lamin A, which affects the nuclear scaffolding. The phenotypic hallmark of HGPS is nuclear blebbing. Interestingly, similar nuclear blebbing has also been observed in aged cells from healthy individuals. R...

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Detalhes bibliográficos
Main Authors: Driscoll, Meghan K., Albanese, Jason L., Xiong, Zheng-Mei, Mailman, Mitch, Losert, Wolfgang, Cao, Kan
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3314174/
https://ncbi.nlm.nih.gov/pubmed/22354768
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