The Voltage–gated Proton Channel, Hv1, Enhances Brain Damage from Ischemic Stroke

Phagocytic cell NADPH oxidase (NOX) generates reactive oxygen species (ROS) as part of innate immunity. Unfortunately, ischemia can also induce this pathway and inflict damage on native cells. Here we show that NOX–mediated damage can be inhibited by suppression of the voltage-gated proton channel,...

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Bibliographische Detailangaben
Hauptverfasser: Wu, Long–Jun, Wu, Gongxiong, Akhavan Sharif, M. Reza, Baker, Amanda, Jia, Yonghui, H. Fahey, Frederic, Luo, Hongbo R., Feener, Edward P., Clapham, David E.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2012
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3314139/
https://ncbi.nlm.nih.gov/pubmed/22388960
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nn.3059
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