Prevalence of the BRCA1 founder mutation c.5266dupin Brazilian individuals at-risk for the hereditary breast and ovarian cancer syndrome

About 5-10% of breast and ovarian carcinomas are hereditary and most of these result from germline mutations in the BRCA1 and BRCA2 genes. In women of Ashkenazi Jewish ascendance, up to 30% of breast and ovarian carcinomas may be attributable to mutations in these genes, where 3 founder mutations, c...

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Bibliografske podrobnosti
Main Authors: Ewald, Ingrid P, Izetti, Patrícia, Vargas, Fernando R, Moreira, Miguel AM, Moreira, Aline S, Moreira-Filho, Carlos A, Cunha, Danielle R, Hamaguchi, Sara, Camey, Suzi A, Schmidt, Aishameriane, Caleffi, Maira, Koehler-Santos, Patrícia, Giugliani, Roberto, Ashton-Prolla, Patricia
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2011
Teme:
Research
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3313847/
https://ncbi.nlm.nih.gov/pubmed/22185575
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1897-4287-9-12
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