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Emerging Therapeutics Targeting mRNA Translation
A defining feature of many cancers is deregulated translational control. Typically, this occurs at the level of recruitment of the 40S ribosomes to the 5′-cap of cellular messenger RNAs (mRNAs), the rate-limiting step of protein synthesis, which is controlled by the heterotrimeric eukaryotic initiat...
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| Autores principales: | , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
Cold Spring Harbor Laboratory Press
2012
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3312682/ https://ncbi.nlm.nih.gov/pubmed/22474009 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/cshperspect.a012377 |
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