LincRNA-p21 suppresses target mRNA translation

Mammalian long intergenic noncoding (linc)RNAs are best known for modulating transcription. Here we report a post-transcriptional function for lincRNA-p21 as a modulator of translation. Association of the RNA-binding protein HuR with lincRNA-p21 favored the recruitment of let-7/Ago2 to lincRNA-p21,...

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Huvudupphovsmän: Yoon, Je-Hyun, Abdelmohsen, Kotb, Srikantan, Subramanya, Yang, Xiaoling, Martindale, Jennifer L., De, Supriyo, Huarte, Maite, Zhan, Ming, Becker, Kevin G., Gorospe, Myriam
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2012
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3509343/
https://ncbi.nlm.nih.gov/pubmed/22841487
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2012.06.027
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