Interaction of berenil with the tyrT DNA sequence studied by footprinting and molecular modelling. Implications for the design of sequence-specific DNA recognition agents.

We have developed a technique of partially-restrained molecular mechanics enthalpy minimisation which enables the sequence-dependence of the DNA binding of a non-intercalating ligand to be studied for arbitrary sequences of considerable length (greater than = 60 base-pairs). The technique has been a...

Popoln opis

Shranjeno v:
Bibliografske podrobnosti
Main Authors: Laughton, C A, Jenkins, T C, Fox, K R, Neidle, S
Format: Artigo
Jezik:Inglês
Izdano: 1990
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC331268/
https://ncbi.nlm.nih.gov/pubmed/2167469
Oznake: Označite
Brez oznak, prvi označite!

Podobne knjige/članki