Exploiting Adaptive Laboratory Evolution of Streptomyces clavuligerus for Antibiotic Discovery and Overproduction

Adaptation is normally viewed as the enemy of the antibiotic discovery and development process because adaptation among pathogens to antibiotic exposure leads to resistance. We present a method here that, in contrast, exploits the power of adaptation among antibiotic producers to accelerate the disc...

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Bibliographic Details
Main Authors: Charusanti, Pep, Fong, Nicole L., Nagarajan, Harish, Pereira, Alban R., Li, Howard J., Abate, Elisa A., Su, Yongxuan, Gerwick, William H., Palsson, Bernhard O.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2012
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3312335/
https://ncbi.nlm.nih.gov/pubmed/22470465
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0033727
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