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Exploiting Adaptive Laboratory Evolution of Streptomyces clavuligerus for Antibiotic Discovery and Overproduction

Adaptation is normally viewed as the enemy of the antibiotic discovery and development process because adaptation among pathogens to antibiotic exposure leads to resistance. We present a method here that, in contrast, exploits the power of adaptation among antibiotic producers to accelerate the disc...

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Detalhes bibliográficos
Main Authors: Charusanti, Pep, Fong, Nicole L., Nagarajan, Harish, Pereira, Alban R., Li, Howard J., Abate, Elisa A., Su, Yongxuan, Gerwick, William H., Palsson, Bernhard O.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3312335/
https://ncbi.nlm.nih.gov/pubmed/22470465
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0033727
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