Cathepsin L Activity Is Essential to Elastase Perfusion–Induced Abdominal Aortic Aneurysms in Mice

OBJECTIVE: The development of abdominal aortic aneurysms (AAA) requires extensive aortic wall matrix degradation. Human AAA lesions express high levels of cathepsin L (CatL), one of the most potent mammalian elastases. Whether this protease participates directly in AAA pathogenesis, however, is unkn...

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Main Authors: Sun, Jiusong, Sukhova, Galina K., Zhang, Jie, Chen, Han, Sjöberg, Sara, Libby, Peter, Xiang, Meixiang, Wang, Jianan, Peters, Christoph, Reinheckel, Thomas, Shi, Guo-Ping
Format: Artigo
Sprog:Inglês
Udgivet: 2011
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3312037/
https://ncbi.nlm.nih.gov/pubmed/21868704
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.111.230201
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