Cathepsin K Deficiency Reduces Elastase Perfusion-Induced Abdominal Aortic Aneurysms in Mice

OBJECTIVES: Cathepsin K (CatK) is one of the most potent mammalian elastases. We have previously shown increased expression of CatK in human abdominal aortic aneurysm (AAA) lesions. Whether this protease participates directly in AAA formation, however, remains unknown. METHODS AND RESULTS: Mouse exp...

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Bibliografiske detaljer
Main Authors: Sun, Jiusong, Sukhova, Galina K., Zhang, Jie, Chen, Han, Sjöberg, Sara, Libby, Peter, Xia, Mingcan, Xiong, Na, Gelb, Bruce D., Shi, Guo-Ping
Format: Artigo
Sprog:Inglês
Udgivet: 2011
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3230668/
https://ncbi.nlm.nih.gov/pubmed/21817099
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.111.235002
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