SYNERGISTIC EFFECT OF NOREPINEPHRINE TRANSPORTER BLOCKADE AND ALPHA-2 ANTAGONISM ON BLOOD PRESSURE IN AUTONOMIC FAILURE

Patients with autonomic failure have disabling orthostatic hypotension due to impaired sympathetic activity. Norepinephrine transporter (NET) blockade with atomoxetine raises blood pressure in autonomic failure by increasing synaptic norepinephrine concentrations in postganglionic sympathetic neuron...

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Main Authors: Okamoto, Luis E., Shibao, Cyndya, Gamboa, Alfredo, Choi, Leena, Diedrich, André, Raj, Satish R., Black, Bonnie K., Robertson, David, Biaggioni, Italo
Formato: Artigo
Idioma:Inglês
Publicado: 2012
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3312003/
https://ncbi.nlm.nih.gov/pubmed/22311903
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/HYPERTENSIONAHA.111.184812
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