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Differential risk of tuberculosis reactivation among anti-TNF therapies is due to drug binding kinetics and permeability

Increased rates of tuberculosis (TB) reactivation have been reported in humans treated with tumor necrosis factor-α (TNF)-neutralizing drugs, and higher rates are observed with anti-TNF antibodies (e.g. infliximab) as compared with TNF receptor fusion protein (etanercept). Mechanisms driving differe...

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Detalhes bibliográficos
Main Authors: Fallahi-Sichani, Mohammad, Flynn, JoAnne L., Linderman, Jennifer J., Kirschner, Denise E.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3311778/
https://ncbi.nlm.nih.gov/pubmed/22379032
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1103298
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