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Rational Design and Characterization of D-Phe-Pro-D-Arg-Derived Direct Thrombin Inhibitors

The tremendous social and economic impact of thrombotic disorders, together with the considerable risks associated to the currently available therapies, prompt for the development of more efficient and safer anticoagulants. Novel peptide-based thrombin inhibitors were identified using in silico stru...

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Bibliografische gegevens
Hoofdauteurs: Figueiredo, Ana C., Clement, Cristina C., Zakia, Sheuli, Gingold, Julian, Philipp, Manfred, Pereira, Pedro J. B.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Public Library of Science 2012
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3311629/
https://ncbi.nlm.nih.gov/pubmed/22457833
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0034354
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