Puerarin Induces Mitochondria-Dependent Apoptosis in Hypoxic Human Pulmonary Arterial Smooth Muscle Cells

BACKGROUND: Pulmonary vascular medial hypertrophy in hypoxic pulmonary arterial hypertension (PAH) is caused in part by decreased apoptosis in pulmonary artery smooth muscle cells (PASMCs). Puerarin, an isoflavone purified from the Chinese medicinal herb kudzu, ameliorates chronic hypoxic PAH in ani...

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Autori principali: Chen, Chan, Chen, Chun, Wang, Zhiyi, Wang, Liangxing, Yang, Lehe, Ding, Minjiao, Ding, Cheng, Sun, Yu, Lin, Quan, Huang, Xiaoying, Du, Xiaohong, Zhao, Xiaowei, Wang, Chuangyi
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2012
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3311615/
https://ncbi.nlm.nih.gov/pubmed/22457823
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0034181
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