Common Genetic Variation in the SERPINF1 Locus Determines Overall Adiposity, Obesity-Related Insulin Resistance, and Circulating Leptin Levels

OBJECTIVE: Pigment epithelium-derived factor (PEDF) belongs to the serpin family of peptidase inhibitors (serpin F1) and is among the most abundant glycoproteins secreted by adipocytes. In vitro and mouse in vivo data revealed PEDF as a candidate mediator of obesity-induced insulin resistance. There...

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Hlavní autoři: Böhm, Anja, Ordelheide, Anna-Maria, Machann, Jürgen, Heni, Martin, Ketterer, Caroline, Machicao, Fausto, Schick, Fritz, Stefan, Norbert, Fritsche, Andreas, Häring, Hans-Ulrich, Staiger, Harald
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2012
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3311576/
https://ncbi.nlm.nih.gov/pubmed/22457810
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0034035
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